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SASInstitute A00-282 Exam Syllabus Topics:
| Section | Weight | Objectives |
|---|---|---|
| Topic 1: Apply Statistical Procedures for Clinical Trials | 15% | - Basic statistical analysis for clinical data - PROC MEANS, FREQ, TABULATE |
| Topic 2: Validate Clinical Trial Data Reporting | 20% | - Validation principles - Use PROC COMPARE and log review - Programming validation techniques |
| Topic 3: Manage Clinical Trials Data | 5% | - Access and explore clinical datasets - Use SQL and dictionary tables - Clean, merge, and subset data |
| Topic 4: Macro Programming for Clinical Trials | 15% | - Debugging macros - Create and call macros - Macro variables and parameters |
| Topic 5: Report Clinical Trials Results | 10% | - Produce tables, listings, and figures - PROC REPORT and PROC PRINT |
| Topic 6: Transform or Summarize Clinical Trials Data | 15% | - Data step manipulation - Aggregation and transposition - Derive variables and study days |
| Topic 7: Regulatory Submissions | 5% | - Compliance for clinical data reporting - ICH and FDA guidelines |
| Topic 8: Clinical Trials Process | 5% | - Derive programming requirements from protocol and CRF - Clinical trial lifecycle and protocol |
| Topic 9: Clinical Trials Data Structures | 10% | - Define.xml and dataset specifications - CDISC standards: SDTM, ADaM - Clinical domain structures |
SASInstitute Clinical Trials Programming Using SAS 9.4 Sample Questions:
1. A dataset contains systolic blood pressure values stored in the variable SYSBP.
Which program displays the median systolic blood pressure over all participants?
A) proc freq data=vitals;
tables sysbp;
run;
B) proc summary data=vitals print;
var sysbp;
run;
C) proc means data=vitals;
var sysbp;
run;
D) proc univariate data=vitals;
var sysbp;
run;
2. Given the data set HE:
What will the values be of variable HOSPDURD for the two subjects?
A) missing, missing
B) 50, 9
C) 5, missing
D) 65, 9
3. A statistical analysis plan asks you to create a table with the following counts of adverse events:
- the number adverse events in each system organ class (AESOC)
- within each level of system organ class, the number of adverse events with each preferred term (AEPT).
Which code produces the counts requested?
A) proc freq data=AE:
tables AESOC, AEPT;
run;
B) proc freq data=AE;
tables AESOC*AEPT;
run;
C) proc freq data=AE;
tables AESOC AEPT;
run;
D) proc freq data=AE;
tables AESOC (AEPT);
run;
4. Which code segment includes a statement that would reset the graphics counter and ensure a 6in by
4in image is produced?
A) ods graphics / reset width = 6in height = 4in;
B) ods graphics / width = 6in height = 4in reset;
C) ods graphics / width = 6in height = 4in counter = 1;
D) ods graphics / counter = 1 width = 6in height = 4in;
5. This question will ask you to provide a line of missing code.
Which line of code would produce the blue notes in the log?
A) if indm ne indisp then put 'MERGE ISSUE: ' subjid= indm= indisp=;
B) if indm ne indisp then output 'MERGE ISSUE: ' subjid indm indisp;
C) %if indm ne indisp %then %put 'MERGE ISSUE: ' subjid= indm= indisp=;
D) if indm ne indisp then put 'MERGE ISSUE: ' _all_;
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: A | Question # 3 Answer: B | Question # 4 Answer: A | Question # 5 Answer: A |
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